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Chargers vs. Jaguars, 49ers vs. Cardinals: NFL Week 11 odds, picks

November 16, 2025
in Sports
Reading Time: 4 mins read
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Chargers vs. Jaguars, 49ers vs. Cardinals: NFL Week 11 odds, picks
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Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

Post sports gambling editor/producer and digital sports editor Matt Ehalt is back for his second season in the NFL Bettor’s Guide.

Chargers (-3) over JAGUARS

These two teams are heading in opposite directions.

The Chargers have won three straight, including two against playoff contenders in the Vikings and Steelers.

The Jaguars, meanwhile, are 1-3 in their last four, and the only win came against the lowly Raiders in overtime.

It’s possible that last week’s devastating choke against the Davis Mills-led Texans may spell doom for Jacksonville’s season, while the Chargers can move into first place in the AFC West this week with a win and a Broncos loss to the Chiefs.

Los Angeles has a defense that can give Trevor Lawrence fits, especially considering Jacksonville’s receiving room being in a state of flux.

Let’s back the better team with the better quarterback and the better coach that’s playing a better brand of football.


Chargers vs. Jaguars, 49ers vs. Cardinals: NFL Week 11 odds, picks
George Kittle and the 49ers visit the Cardinals on Sunday. IMAGN IMAGES via Reuters Connect

49ers (-2.5) over CARDINALS

The 49ers burned us last week against the Rams, but this seems like a must-win game for a team in the NFC playoff picture.

The Cardinals have played better with Jacoby Brissett as their quarterback compared to Kyler Murray, but they have lost six of seven, including last week’s 44-22 beatdown served by the Seahawks.


Betting on the NFL?


They will now have to try to find a way to win without their top two running backs and star receiver Marvin Harrison Jr., who just underwent surgery.

San Francisco’s injury-riddled defense isn’t great, as shown last week when it allowed 42 points, but Robert Saleh can attempt to neutralize star tight end Trey McBridge on each play.

We’re going to back the team that has much more at stake versus the franchise already dealing with headlines about whether its pricey quarterback will still be on the roster in 2026.

2025 record: 5-14-1
Last week: 0-2; 49ers (L); Panthers (L)

Why Trust New York Post Betting

Matt Ehalt has been picking against the spread since his childhood days when he entered his father’s newspaper pool and even took the top prize on more than one occasion. He specializes in NFL wagers and is quite successful with NCAA brackets.

Credit: Source link

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